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The 73 reference on this shirt is from Season 4, Episode 10, The Alien Parasite Hypothesis - which of course is the 73rd episode). According to Sheldon- "The best number is 73... 73 is the twenty-first prime number. Its mirror, 37, is the twelfth and its mirror, 21, is the product of multiplying (hang on to your hats) 7 and 3... In binary, 73 is a palindrome: 1-0-0-1-0-0-1, which backwards is 1-0-0-1-0-0-1." Get your nerd on with this awesome selection from Sheldon's closet and it will be the most intelligent decision you make about your wardrobe !