From the streets of Baltimore, Maryland hail an all girl clique called the Pussy Pound. At the head of the clique is Netta, at her side is her close friend, Mimi. Both women are armed with a do anything-for-the-money attitude. Quickly it becomes clear that Netta will go above and beyond the call of duty in her quest for the almighty dollar. Under her tutelage the Pussy Pound becomes infamous on the streets of Baltimore as they attract and target some of the most prominent dope boys in the city. With each hustler that they bed the Pussy Pound becomes more deeply entangled in the game.
As the consequences of their acts catch up to them. They soon discover that the streets of Baltimore are an unforgiving place and there is a heavy price to pay for their treachery.