The inquiry based SE lesson in iScience will encourage every student to say, "I want to know!" Engaging students is easy when they do relevant labs and use technology inspired by digital natives. Motivate students and spark their curiosity through the research-based, relevant activities in iScience. Effective instruction hinges on innovative instructional strategies such as Understanding by Design and Page Keeley Science Probes. This volume includes -Nature of Science: Methods of Science. -Unit 1, Exploring Earth (Mapping Earth, Earth in Space, Our Planet-Earth, Earth's Dynamic Surface, Natural Resources) -Unit 2, Exploring Life ( Life's Classification and Structure, Inheritance and Adaptations, Introduction to Plants, Introduction to Animals, Interactions of Life)