Struggling actress and full-time waitress, Cassandra Taylor, is having one of the worst days of her life. Rude customers, a cheating boyfriend, and a botched audition are just the tip of the iceberg. Her new neighbor, Ryan McCallistar, has troubles of his own but neither is aware of a growing threat in the underbelly of New York City. Contrary to what the media reports, their so-called flu epidemic is actually a viral plague turning humans into flesh-eating monsters.
Starting on the streets, New York€s homeless are a walking buffet for the reanimated dead. One bite kick-starts a catastrophic outbreak turning the dead into ravenous fiends, bent on devouring flesh from bone. As the infection spreads, people from all walks of life are doomed to a ravenous search for fresh meat. On the same day the governor declares a state of emergency, Cassie learns her grandfather is deathly ill and her family in Ohio begs her to come back home. Ryan vows to help his neighbor find a way to Ohio but to do it, they must escape the watchful eye of every guard employed to patrol the border.
Cassie and Ryan risk life and limb to escape the horrors in The Big Apple but that€s only the beginning of their journey. Can they endure the trek through a zombie-infested wasteland and survive the New York Outbreak?