INDICATIONS:Prilosec OTC provides heartburn treatment for frequent heartburn that occurs 2 or more days a week. 24 hours of heartburn relief. -Prilosec OTC is the first and original OTC frequent heartburn medicine. -Prilosec OTC contains the active ingredient (in each tablet): Omeprazole delayed-release tablet 20mg (equivalent to 20.6mg omeprazole magnesium).