Spider-Man battles the most dangerous Sinister Six line-up ever: Doctor Octopus, Electro, Mysterio, the Vulture, the tragic but deadly Pity, and the group's mysterious leader, the Gentleman - a villain who had a hand in the deaths of Spider-Man's parents! But what neither Spider-Man nor his enemies know is that the Gentleman is about to set his master plan into motion: destroying all the financial markets in the world and make himself the richest man in the world. As for the villainess Pity, Spider-Man has become convinced that she is his long-lost sister. But to get Pity to reject her life of crime and break free of the Gentleman's control, he needs conclusive proof - proof that only the X-Man known as Wolverine has. But time is running out for Spider-Man, for Pity, and for the world.