Henry Wallace, now a fugitive and narrowly escaping death in Denver, is on his way to Cheyenne with Samantha in her medicine wagon. The pair discovers a farm house with a man dying under suspicious circumstances, and the wife refuses Henry's help as a doctor.
Samantha gets into big trouble with the law in Cheyenne and Henry goes to great lengths to bail her out. He risks life and limb during a free-for-all in which the last man standing gets the $400 prize money. Henry must depend on his prowess as a boxer to save himself when he is involved in a battle of intense brutality. The battle is the most terrifying and brutal experience of Henry's life.