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The Birthmark
Hawthorne approached the Romantic notion of the ability of science to destroy art (or beauty) in the form of fictive "horror stories" of biological research out of control. This story is the best of that group. A devoted scientist marries a beautiful woman with a single physical flaw: a birthmark on her face. Aylmer becomes obsessed with the imperfection and his attempts to remove it via his scientific skills, thus rendering his bride perfect.