Dr. Austin Sloper, a wealthy and highly successful physician, lives in Washington Square, New York, with his daughter Catherine. Catherine is a sweet-natured young woman who is a great disappointment to her father, being physically plain and, he believes, dull in terms of personality and intellect. His sister, Lavinia Penniman, a meddlesome woman with a weakness for romance and melodrama, is the only other member of the doctor's household.